Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder worldwide. Currently, the only strategy for palliative treatment of AD is to inhibit acetylcholinesterase (AChE) in order to increase the concentration of acetylcholine in the synaptic cleft. Evidence indicates that AChE also...

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Bibliographic Details
Main Authors: Susimaire P. Mantoani, Talita P. C. Chierrito, Adriana F. L. Vilela, Carmen L. Cardoso, Ana Martínez, Ivone Carvalho
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/21/2/193