The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity

The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity

Thimet oligopeptidase (EC 3.4.24.15; EP24.15; THOP1) is a potential therapeutic target, as it plays key biological functions in processing biologically functional peptides. The structural conformation of THOP1 provides a unique restriction regarding substrate size, in that it only hydrolyzes peptide...

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Main Authors: Mayara C. F. Gewehr, Alexandre A. S. Teixeira, Bruna A. C. Santos, Luana A. Biondo, Fábio C. Gozzo, Amanda M. Cordibello, Rosangela A. S. Eichler, Patrícia Reckziegel, Renée N. O. Da Silva, Nilton B. Dos Santos, Niels O. S. Camara, Angela Castoldi, Maria L. M. Barreto-Chaves, Camila S. Dale, Nathalia Senger, Joanna D. C. C. Lima, Marilia C. L. Seelaender, Aline C. Inada, Eliana H. Akamine, Leandro M. Castro, Alice C. Rodrigues, José C. Rosa Neto, Emer S. Ferro
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
obesity
insulin resistance
diet-induced obesity
proteasome
proteases
peptidases
mass spectrometry
peptidome
Online Access:https://www.mdpi.com/2218-273X/10/2/321

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