Erythropoietin receptor signaling is membrane raft dependent.

Erythropoietin receptor signaling is membrane raft dependent.

Upon erythropoietin (Epo) engagement, Epo-receptor (R) homodimerizes to activate JAK2 and Lyn, which phosphorylate STAT5. Although recent investigations have identified key negative regulators of Epo-R signaling, little is known about the role of membrane localization in controlling receptor signal...

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Bibliographic Details
Main Authors: Kathy L McGraw, Gwenny M Fuhler, Joseph O Johnson, Justine A Clark, Gisela C Caceres, Lubomir Sokol, Alan F List
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3317978?pdf=render

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