Biochemical changes in polymorphonuclear leucocytes in diabetic patients.

• Main Author: Sawant J
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 1993-10-01
• Series: Journal of Postgraduate Medicine
• Subjects: Adult; Case-Control Studies; Diabetes Mellitus; complications; Female; Human; Infection; etiology; Lysosomes; chemistry; Male; Neutrophils; Phagocyte Bactericidal Dysfunction; blood; epidemiology; Recurrence; Support; Non-U.S. Gov′t
• Online Access: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1993;volume=39;issue=4;spage=183;epage=6;aulast=Sawant
• ISSN: 0022-3859; 0972-2823

A study on the functional ability of polymorphonuclear leucocytes (PMNL) indicates that the total lysosomal enzyme levels viz. Beta-glucuronidase, lysozyme, acid phosphatase and alkaline phosphatase were not altered in diabetics, compared to that in control subjects. However, the findings also reveal that the release of these lysosomal enzymes in response to a particulate stimulus is impaired in diabetics. This suggests that the bactericidal capacity of these cells, which are involved in phagocytosis, is impaired in diabetics, making them more vulnerable to infections.