Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway

Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway

Recently, we has reported that AMPK activator has antidepressant effect. Previous our study suggested that liver hydrolysate (LH) activated adenosine monophosphate-activated protein kinase (AMPK) in periphery. However, the effect of LH on depression is unclear. Therefore, we examines whether LH has...

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Main Authors: Osamu Nakagawasai, Kotaro Yamada, Takayo Odaira, Kohei Takahashi, Wataru Nemoto, Wakana Sakuma, Miharu Wakou, Jia-Rong Lin, Koichi Tan-No
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300037
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spelling doaj-cd1380a0456345859d82a7aae389c4552020-11-25T02:29:03ZengElsevierJournal of Pharmacological Sciences1347-86132020-05-0114315255Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathwayOsamu Nakagawasai0Kotaro Yamada1Takayo Odaira2Kohei Takahashi3Wataru Nemoto4Wakana Sakuma5Miharu Wakou6Jia-Rong Lin7Koichi Tan-No8Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan; Corresponding author. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan Fax: +81 22 727 0123.Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., 10-11, Nihonbashi Kobuna-cho, Chuo-ku, Tokyo, 103-8351, JapanDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JapanDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, JapanDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JapanDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JapanDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JapanDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JapanDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, JapanRecently, we has reported that AMPK activator has antidepressant effect. Previous our study suggested that liver hydrolysate (LH) activated adenosine monophosphate-activated protein kinase (AMPK) in periphery. However, the effect of LH on depression is unclear. Therefore, we examines whether LH has antidepressant effect on olfactory bulbectomized (OBX) mice. OBX mice showed depressive-like behavior in tail-suspension test and reduction of hippocampal neurogenesis, while these changes were reversed by LH. LH enhanced hippocampal phosphate-AMPK, brain-derived neurotrophic factor (BDNF) and phosphate-cyclic adenosine monophosphate response element-binding protein (CREB) in OBX mice. These data indicate that LH may produce antidepressant effects via hippocampal AMPK/BDNF/CREB signaling. Keywords: Antidepressant, Olfactory bulbectomy, Liver hydrolysatehttp://www.sciencedirect.com/science/article/pii/S1347861320300037
collection DOAJ
language English
format Article
sources DOAJ
author Osamu Nakagawasai
Kotaro Yamada
Takayo Odaira
Kohei Takahashi
Wataru Nemoto
Wakana Sakuma
Miharu Wakou
Jia-Rong Lin
Koichi Tan-No
spellingShingle Osamu Nakagawasai
Kotaro Yamada
Takayo Odaira
Kohei Takahashi
Wataru Nemoto
Wakana Sakuma
Miharu Wakou
Jia-Rong Lin
Koichi Tan-No
Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway
Journal of Pharmacological Sciences
author_facet Osamu Nakagawasai
Kotaro Yamada
Takayo Odaira
Kohei Takahashi
Wataru Nemoto
Wakana Sakuma
Miharu Wakou
Jia-Rong Lin
Koichi Tan-No
author_sort Osamu Nakagawasai
title Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway
title_short Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway
title_full Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway
title_fullStr Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway
title_full_unstemmed Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway
title_sort liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: involvement of hippocampal neurogenesis through the ampk/bdnf/creb pathway
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2020-05-01
description Recently, we has reported that AMPK activator has antidepressant effect. Previous our study suggested that liver hydrolysate (LH) activated adenosine monophosphate-activated protein kinase (AMPK) in periphery. However, the effect of LH on depression is unclear. Therefore, we examines whether LH has antidepressant effect on olfactory bulbectomized (OBX) mice. OBX mice showed depressive-like behavior in tail-suspension test and reduction of hippocampal neurogenesis, while these changes were reversed by LH. LH enhanced hippocampal phosphate-AMPK, brain-derived neurotrophic factor (BDNF) and phosphate-cyclic adenosine monophosphate response element-binding protein (CREB) in OBX mice. These data indicate that LH may produce antidepressant effects via hippocampal AMPK/BDNF/CREB signaling. Keywords: Antidepressant, Olfactory bulbectomy, Liver hydrolysate
url http://www.sciencedirect.com/science/article/pii/S1347861320300037
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