Knockout mice: is it just genetics? Effect of enriched housing on fibulin-4(+/-) mice.

Knockout mice: is it just genetics? Effect of enriched housing on fibulin-4(+/-) mice.

Fibulin-4 is an extracellular matrix protein expressed by vascular smooth muscle cells that is essential for maintaining arterial integrity. Fibulin-4(-/-) mice die just before birth due to arterial hemorrhage, but fibulin-4(+/-) mice appear to be outwardly normal. Experiments were therefore perform...

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Bibliographic Details
Main Authors: Elizabeth Cudilo, Hamda Al Naemi, Lihua Marmorstein, Ann L Baldwin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1794134?pdf=render

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