Knockout mice: is it just genetics? Effect of enriched housing on fibulin-4(+/-) mice.
Fibulin-4 is an extracellular matrix protein expressed by vascular smooth muscle cells that is essential for maintaining arterial integrity. Fibulin-4(-/-) mice die just before birth due to arterial hemorrhage, but fibulin-4(+/-) mice appear to be outwardly normal. Experiments were therefore perform...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-02-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1794134?pdf=render |