Time of Day-Dependent Alterations in Hippocampal Kynurenic Acid, Glutamate, and GABA in Adult Rats Exposed to Elevated Kynurenic Acid During Neurodevelopment

Time of Day-Dependent Alterations in Hippocampal Kynurenic Acid, Glutamate, and GABA in Adult Rats Exposed to Elevated Kynurenic Acid During Neurodevelopment

Hypofunction of glutamatergic signaling is causally linked to neurodevelopmental disorders, including psychotic disorders like schizophrenia and bipolar disorder. Kynurenic acid (KYNA) has been found to be elevated in postmortem brain tissue and cerebrospinal fluid of patients with psychotic illness...

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Bibliographic Details
Main Authors: Courtney J. Wright, Katherine M. Rentschler, Nathan T. J. Wagner, Ashley M. Lewis, Sarah Beggiato, Ana Pocivavsek
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Psychiatry
Subjects:
kynurenine
NMDA receptor
schizophrenia
psychotic disorders
prenatal
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.734984/full

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