LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair

LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair

Low-density lipoprotein receptor-related protein-1 (LRP1) is a large endocytic and signaling molecule broadly expressed by neurons and glia. In adult mice, global inducible (Lrp1flox/flox;CAG-CreER) or oligodendrocyte (OL)-lineage specific ablation (Lrp1flox/flox;Pdgfra-CreER) of Lrp1 attenuates rep...

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Bibliographic Details
Main Authors: Jing-Ping Lin, Yevgeniya A Mironova, Peter Shrager, Roman J Giger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
CNS Myelin Repair
Oligodendrocyte differentiation
Peroxisome Biogenesis
Cholesterol Homeostasis
LRP1
mouse
Online Access:https://elifesciences.org/articles/30498

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