Regulatory Immunotherapy in Bone Marrow Transplantation

Regulatory Immunotherapy in Bone Marrow Transplantation

Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populati...

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Main Authors: Vanessa Morales-Tirado, Wioleta Luszczek, Marié van der Merwe, Asha Pillai
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2011/768948
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spelling doaj-ccf6f8acc2f54840aa67ba8d7773cbf92020-11-25T02:31:25ZengHindawi LimitedThe Scientific World Journal1537-744X2011-01-01112620263410.1100/2011/768948768948Regulatory Immunotherapy in Bone Marrow TransplantationVanessa Morales-Tirado0Wioleta Luszczek1Marié van der Merwe2Asha Pillai3Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USADepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USADepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USADepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USAEvery year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.http://dx.doi.org/10.1100/2011/768948
collection DOAJ
language English
format Article
sources DOAJ
author Vanessa Morales-Tirado
Wioleta Luszczek
Marié van der Merwe
Asha Pillai
spellingShingle Vanessa Morales-Tirado
Wioleta Luszczek
Marié van der Merwe
Asha Pillai
Regulatory Immunotherapy in Bone Marrow Transplantation
The Scientific World Journal
author_facet Vanessa Morales-Tirado
Wioleta Luszczek
Marié van der Merwe
Asha Pillai
author_sort Vanessa Morales-Tirado
title Regulatory Immunotherapy in Bone Marrow Transplantation
title_short Regulatory Immunotherapy in Bone Marrow Transplantation
title_full Regulatory Immunotherapy in Bone Marrow Transplantation
title_fullStr Regulatory Immunotherapy in Bone Marrow Transplantation
title_full_unstemmed Regulatory Immunotherapy in Bone Marrow Transplantation
title_sort regulatory immunotherapy in bone marrow transplantation
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2011-01-01
description Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.
url http://dx.doi.org/10.1100/2011/768948
work_keys_str_mv AT vanessamoralestirado regulatoryimmunotherapyinbonemarrowtransplantation
AT wioletaluszczek regulatoryimmunotherapyinbonemarrowtransplantation
AT marievandermerwe regulatoryimmunotherapyinbonemarrowtransplantation
AT ashapillai regulatoryimmunotherapyinbonemarrowtransplantation
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