ROLE OF SYMPATHETIC NERVOUS SYSTEM IN THE DEVELOPMENT AND PREVENTION OF EROSIVE ULCER LESIONS OF MUCOUS COAT IN GASTRO-DUODENAL AREA

• Main Authors: O. N. Zabrodin, V. I. Strashnov
• Format: Article
• Language: Russian
• Published: NEW TERRA Publishing House 2018-01-01
• Series: Вестник анестезиологии и реаниматологии
• Subjects: sympathetic nervous system; mucous coat of gastro-duodenal area; erosive-ulcer lesions of mucous coat; spinal anesthesia; epidural anesthesia; combined spinal-epidural anesthesia
• Online Access: https://www.vair-journal.com/jour/article/view/88

The articles presents the review of data about pathogenesis of stress erosive ulcer lesions of mucous coat in gastro-duodenal area. Imbalance between protection factors of mucous coat and aggression factors towards the latter (ischemia of mucous coat, microcirculation disorders in it, activation of free radical oxidation, acidopeptic factor etc) is recognized as a main pathogenic moment. The presented data are discussed from the point of view of sympathetic nervous system (SNS) for nervous trophism and its disorders – neurogenic dystrophia of internal organs caused by stress hyperactivation of SNS and consequent atrophy of its mediator of norepinephrine in the tissue of internal organs. These norepinephrine balance disorders are crucial regarding development of erosive ulcer lesions of mucous coat. Spinal anesthesia, epidural anesthesia and combined spinal-epidural anesthesia prevent development of numerous post-surgery complications when used during surgery.