Quantifying global tolerance of biochemical systems: design implications for moiety-transfer cycles.

Robustness of organisms is widely observed although difficult to precisely characterize. Performance can remain nearly constant within some neighborhood of the normal operating regime, leading to homeostasis, but then abruptly break down with pathological consequences beyond this neighborhood. Curre...

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Bibliographic Details
Main Authors: Pedro M B M Coelho, Armindo Salvador, Michael A Savageau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2650413?pdf=render

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