Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents

Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents

Animal models of stress and related conditions, including depression, have shown that elevated peripheral levels of inflammatory cytokines have downstream consequences on glutamate (Glu) in the brain. Although studies in human adults with depression have reported evidence of higher inflammation but...

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Bibliographic Details
Main Authors: Tiffany C. Ho, Giana I. Teresi, Jillian R. Segarra, Amar Ojha, Johanna C. Walker, Meng Gu, Daniel M. Spielman, Matthew D. Sacchet, Fei Jiang, Yael Rosenberg-Hasson, Holden Maecker, Ian H. Gotlib
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Psychiatry
Subjects:
glutamate
depression
magnetic resonance spectroscopy
interleukin-6
ascorbate
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.642976/full

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