CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-ce...

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Main Authors:	Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-20893-2

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spelling	doaj-ccc6ff85f88e4afdb0a9c7be290f2a3b2021-02-14T12:12:27ZengNature Publishing GroupNature Communications2041-17232021-02-0112111710.1038/s41467-021-20893-2CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapyAlba Rodriguez-Garcia0Rachel C. Lynn1Mathilde Poussin2Monika A. Eiva3Lauren C. Shaw4Roddy S. O’Connor5Nicholas G. Minutolo6Victoria Casado-Medrano7Gonzalo Lopez8Takami Matsuyama9Daniel J. Powell10Department of Pathology and Laboratory Medicine, Ovarian Cancer Research Center, Perelman School of Medicine, University of PennsylvaniaDepartment of Pathology and Laboratory Medicine, Ovarian Cancer Research Center, Perelman School of Medicine, University of PennsylvaniaDepartment of Pathology and Laboratory Medicine, Ovarian Cancer Research Center, Perelman School of Medicine, University of PennsylvaniaDepartment of Pathology and Laboratory Medicine, Ovarian Cancer Research Center, Perelman School of Medicine, University of PennsylvaniaDepartment of Pathology and Laboratory Medicine, Ovarian Cancer Research Center, Perelman School of Medicine, University of PennsylvaniaCenter for Cellular Immunotherapies, Abramson Cancer Center, University of PennsylvaniaDepartment of Pathology and Laboratory Medicine, Ovarian Cancer Research Center, Perelman School of Medicine, University of PennsylvaniaDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of PennsylvaniaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiThe Center for Advanced Biomedical Sciences and Swine Research, Kagoshima UniversityDepartment of Pathology and Laboratory Medicine, Ovarian Cancer Research Center, Perelman School of Medicine, University of PennsylvaniaSeveral strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-cell therapy in pre-clinical models.https://doi.org/10.1038/s41467-021-20893-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell
spellingShingle	Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy Nature Communications
author_facet	Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell
author_sort	Alba Rodriguez-Garcia
title	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_short	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_full	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_fullStr	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_full_unstemmed	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_sort	car-t cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-02-01
description	Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-cell therapy in pre-clinical models.
url	https://doi.org/10.1038/s41467-021-20893-2
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CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

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