Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
Abstract Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects the...
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doaj-ccbb83d862ec443fa467769cf1bb3d112020-11-25T03:02:39ZengBMCLaboratory Animal Research2233-76602018-12-0134422323110.5625/lar.2018.34.4.223Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD ratsJi Eun Kim0Mi Ju Kang1Jun Young Choi2Jin Ju Park3Mi Rim Lee4Bo Ram Song5Hye Ryeong Kim6Ji Won Park7Hyeon Jun Choi8Su Ji Bae9Dae Youn Hwang10Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityAbstract Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects the regulation of gastrointestinal hormones, by examining the concentration of four hormones and the activation of their receptors in the loperamide (Lop)-induced constipation model. Stool parameters, including number, weight and water content, were significantly recovered in the Lop+GEGR treated group, relative to the Lop+ vehicle treated group; however, food intake and water consumption were maintained at a constant level. Also, a similar recovery was detected for thickness of mucosa, muscle and flat luminal surface in the Lop+GEGR treated group. Furthermore, concentration of the four gastrointestinal hormones evaluated, namely, cholecystokinin (CCK), gastrin (GAS), somatostatin (SS) and motilin (MTL), were lower in the Lop+vehicle treated group than the No treated group, but were remarkably enhanced in the Lop+GEGR treated group. Moreover, the downstream signaling pathway of MTL and SS receptors were recovered after GEGR administration. Results of the present study therefore indicate that the laxative effects of GEGR treatment may be tightly related with the regulation of gastrointestinal hormones in the Lop-induced constipation model.http://link.springer.com/article/10.5625/lar.2018.34.4.223ConstipationGalla Rhoislaxative effectgastrointestinal hormonessignaling pathway |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji Eun Kim Mi Ju Kang Jun Young Choi Jin Ju Park Mi Rim Lee Bo Ram Song Hye Ryeong Kim Ji Won Park Hyeon Jun Choi Su Ji Bae Dae Youn Hwang |
spellingShingle |
Ji Eun Kim Mi Ju Kang Jun Young Choi Jin Ju Park Mi Rim Lee Bo Ram Song Hye Ryeong Kim Ji Won Park Hyeon Jun Choi Su Ji Bae Dae Youn Hwang Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats Laboratory Animal Research Constipation Galla Rhois laxative effect gastrointestinal hormones signaling pathway |
author_facet |
Ji Eun Kim Mi Ju Kang Jun Young Choi Jin Ju Park Mi Rim Lee Bo Ram Song Hye Ryeong Kim Ji Won Park Hyeon Jun Choi Su Ji Bae Dae Youn Hwang |
author_sort |
Ji Eun Kim |
title |
Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats |
title_short |
Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats |
title_full |
Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats |
title_fullStr |
Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats |
title_full_unstemmed |
Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats |
title_sort |
regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from galla rhois in loperamide-induced constipation of sd rats |
publisher |
BMC |
series |
Laboratory Animal Research |
issn |
2233-7660 |
publishDate |
2018-12-01 |
description |
Abstract Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects the regulation of gastrointestinal hormones, by examining the concentration of four hormones and the activation of their receptors in the loperamide (Lop)-induced constipation model. Stool parameters, including number, weight and water content, were significantly recovered in the Lop+GEGR treated group, relative to the Lop+ vehicle treated group; however, food intake and water consumption were maintained at a constant level. Also, a similar recovery was detected for thickness of mucosa, muscle and flat luminal surface in the Lop+GEGR treated group. Furthermore, concentration of the four gastrointestinal hormones evaluated, namely, cholecystokinin (CCK), gastrin (GAS), somatostatin (SS) and motilin (MTL), were lower in the Lop+vehicle treated group than the No treated group, but were remarkably enhanced in the Lop+GEGR treated group. Moreover, the downstream signaling pathway of MTL and SS receptors were recovered after GEGR administration. Results of the present study therefore indicate that the laxative effects of GEGR treatment may be tightly related with the regulation of gastrointestinal hormones in the Lop-induced constipation model. |
topic |
Constipation Galla Rhois laxative effect gastrointestinal hormones signaling pathway |
url |
http://link.springer.com/article/10.5625/lar.2018.34.4.223 |
work_keys_str_mv |
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