Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats

Abstract Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects the...

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Main Authors: Ji Eun Kim, Mi Ju Kang, Jun Young Choi, Jin Ju Park, Mi Rim Lee, Bo Ram Song, Hye Ryeong Kim, Ji Won Park, Hyeon Jun Choi, Su Ji Bae, Dae Youn Hwang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Laboratory Animal Research
Subjects:
Online Access:http://link.springer.com/article/10.5625/lar.2018.34.4.223
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spelling doaj-ccbb83d862ec443fa467769cf1bb3d112020-11-25T03:02:39ZengBMCLaboratory Animal Research2233-76602018-12-0134422323110.5625/lar.2018.34.4.223Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD ratsJi Eun Kim0Mi Ju Kang1Jun Young Choi2Jin Ju Park3Mi Rim Lee4Bo Ram Song5Hye Ryeong Kim6Ji Won Park7Hyeon Jun Choi8Su Ji Bae9Dae Youn Hwang10Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityDepartment of Biomaterials Science, College of Natural Resources & Life Science, Pusan National UniversityAbstract Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects the regulation of gastrointestinal hormones, by examining the concentration of four hormones and the activation of their receptors in the loperamide (Lop)-induced constipation model. Stool parameters, including number, weight and water content, were significantly recovered in the Lop+GEGR treated group, relative to the Lop+ vehicle treated group; however, food intake and water consumption were maintained at a constant level. Also, a similar recovery was detected for thickness of mucosa, muscle and flat luminal surface in the Lop+GEGR treated group. Furthermore, concentration of the four gastrointestinal hormones evaluated, namely, cholecystokinin (CCK), gastrin (GAS), somatostatin (SS) and motilin (MTL), were lower in the Lop+vehicle treated group than the No treated group, but were remarkably enhanced in the Lop+GEGR treated group. Moreover, the downstream signaling pathway of MTL and SS receptors were recovered after GEGR administration. Results of the present study therefore indicate that the laxative effects of GEGR treatment may be tightly related with the regulation of gastrointestinal hormones in the Lop-induced constipation model.http://link.springer.com/article/10.5625/lar.2018.34.4.223ConstipationGalla Rhoislaxative effectgastrointestinal hormonessignaling pathway
collection DOAJ
language English
format Article
sources DOAJ
author Ji Eun Kim
Mi Ju Kang
Jun Young Choi
Jin Ju Park
Mi Rim Lee
Bo Ram Song
Hye Ryeong Kim
Ji Won Park
Hyeon Jun Choi
Su Ji Bae
Dae Youn Hwang
spellingShingle Ji Eun Kim
Mi Ju Kang
Jun Young Choi
Jin Ju Park
Mi Rim Lee
Bo Ram Song
Hye Ryeong Kim
Ji Won Park
Hyeon Jun Choi
Su Ji Bae
Dae Youn Hwang
Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
Laboratory Animal Research
Constipation
Galla Rhois
laxative effect
gastrointestinal hormones
signaling pathway
author_facet Ji Eun Kim
Mi Ju Kang
Jun Young Choi
Jin Ju Park
Mi Rim Lee
Bo Ram Song
Hye Ryeong Kim
Ji Won Park
Hyeon Jun Choi
Su Ji Bae
Dae Youn Hwang
author_sort Ji Eun Kim
title Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
title_short Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
title_full Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
title_fullStr Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
title_full_unstemmed Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
title_sort regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from galla rhois in loperamide-induced constipation of sd rats
publisher BMC
series Laboratory Animal Research
issn 2233-7660
publishDate 2018-12-01
description Abstract Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects the regulation of gastrointestinal hormones, by examining the concentration of four hormones and the activation of their receptors in the loperamide (Lop)-induced constipation model. Stool parameters, including number, weight and water content, were significantly recovered in the Lop+GEGR treated group, relative to the Lop+ vehicle treated group; however, food intake and water consumption were maintained at a constant level. Also, a similar recovery was detected for thickness of mucosa, muscle and flat luminal surface in the Lop+GEGR treated group. Furthermore, concentration of the four gastrointestinal hormones evaluated, namely, cholecystokinin (CCK), gastrin (GAS), somatostatin (SS) and motilin (MTL), were lower in the Lop+vehicle treated group than the No treated group, but were remarkably enhanced in the Lop+GEGR treated group. Moreover, the downstream signaling pathway of MTL and SS receptors were recovered after GEGR administration. Results of the present study therefore indicate that the laxative effects of GEGR treatment may be tightly related with the regulation of gastrointestinal hormones in the Lop-induced constipation model.
topic Constipation
Galla Rhois
laxative effect
gastrointestinal hormones
signaling pathway
url http://link.springer.com/article/10.5625/lar.2018.34.4.223
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