Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, lead...

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Main Authors:	Wei Deng, Yan Xu, Wenchun Chen, David S. Paul, Anum K. Syed, Matthew A. Dragovich, Xin Liang, Philip Zakas, Michael C. Berndt, Jorge Di Paola, Jerry Ware, Francois Lanza, Christopher B. Doering, Wolfgang Bergmeier, X. Frank Zhang, Renhao Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12863

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spelling	doaj-cca6cab2d9084967958579b065cd46c92021-05-11T11:10:50ZengNature Publishing GroupNature Communications2041-17232016-09-017111310.1038/ncomms12863Platelet clearance via shear-induced unfolding of a membrane mechanoreceptorWei Deng0Yan Xu1Wenchun Chen2David S. Paul3Anum K. Syed4Matthew A. Dragovich5Xin Liang6Philip Zakas7Michael C. Berndt8Jorge Di Paola9Jerry Ware10Francois Lanza11Christopher B. Doering12Wolfgang Bergmeier13X. Frank Zhang14Renhao Li15Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of MedicineDepartment of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh UniversityDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of MedicineMcAllister Heart Institute, University of North CarolinaDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of MedicineDepartment of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh UniversityDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of MedicineDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of MedicineFaculty of Health Sciences, Curtin UniversityDepartment of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of MedicineDepartment of Physiology and Biophysics, University of Arkansas for Medical SciencesUMR_S949 INSERM, Université de Strasbourg, EFS-AlsaceDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of MedicineMcAllister Heart Institute, University of North CarolinaDepartment of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh UniversityDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of MedicineThe platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance.https://doi.org/10.1038/ncomms12863
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wei Deng Yan Xu Wenchun Chen David S. Paul Anum K. Syed Matthew A. Dragovich Xin Liang Philip Zakas Michael C. Berndt Jorge Di Paola Jerry Ware Francois Lanza Christopher B. Doering Wolfgang Bergmeier X. Frank Zhang Renhao Li
spellingShingle	Wei Deng Yan Xu Wenchun Chen David S. Paul Anum K. Syed Matthew A. Dragovich Xin Liang Philip Zakas Michael C. Berndt Jorge Di Paola Jerry Ware Francois Lanza Christopher B. Doering Wolfgang Bergmeier X. Frank Zhang Renhao Li Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor Nature Communications
author_facet	Wei Deng Yan Xu Wenchun Chen David S. Paul Anum K. Syed Matthew A. Dragovich Xin Liang Philip Zakas Michael C. Berndt Jorge Di Paola Jerry Ware Francois Lanza Christopher B. Doering Wolfgang Bergmeier X. Frank Zhang Renhao Li
author_sort	Wei Deng
title	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_short	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_full	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_fullStr	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_full_unstemmed	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_sort	platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-09-01
description	The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance.
url	https://doi.org/10.1038/ncomms12863
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Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

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