Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, lead...
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Bibliographic Details
| Main Authors: |
Wei Deng,
Yan Xu,
Wenchun Chen,
David S. Paul,
Anum K. Syed,
Matthew A. Dragovich,
Xin Liang,
Philip Zakas,
Michael C. Berndt,
Jorge Di Paola,
Jerry Ware,
Francois Lanza,
Christopher B. Doering,
Wolfgang Bergmeier,
X. Frank Zhang,
Renhao Li |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12863
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