IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury

IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury

Traumatic brain injury (TBI) induces the excessive inflammation and disruption of blood–brain barrier, both of which are partially mediated by the activation of microglia and release of inflammatory cytokines. Previous reports showed that administration of regulatory T cells (Tregs) could suppress i...

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Bibliographic Details
Main Authors: Weiwei Gao, Fei Li, Ziwei Zhou, Xin Xu, Yingang Wu, Shuai Zhou, Dongpei Yin, Dongdong Sun, Jianhua Xiong, Rongcai Jiang, Jianning Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Neurology
Subjects:
traumatic brain injury
IL-2/anti-IL-2
regulatory T cells
microglia
inflammation
blood–brain barrier
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00281/full

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