Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation

Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation

Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial role in excitatory synaptic transmission in the central nervous system. Each subunit contributes with three helical transmembrane segments (M1, M3, and M4) and a pore loop (M2) to form the channel po...

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Bibliographic Details
Main Authors: Kai Langer, Adriana Müller-Längle, Jannik Wempe, Bodo Laube
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
N-methyl-D-aspartate receptor
excitatory glycine receptor
M4
transmembrane segment interactions
pregnenolone sulfate
negative allosteric modulator
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.769046/full

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