Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy

Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy

Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a large subunit called RR1 (α), that contains two allosteric sites and one catalytic site, and a small subunit called RR2 (β), which houses a tyr...

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Bibliographic Details
Main Authors: Prem Singh Kaushal, Qun Wan, Chris G. Dealwis, Jianying Kiser, Hai Xu, James W. Fairman, Andrew Zhang, Sanath R. Wijerathna, Md. Faiz Ahmad
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Pharmaceuticals
Subjects:
ribonucleotide reductase
gemcitabine
clofarabine
cladrabine
P6
P7
Cyc 10
dATP
ATP
allosteric regulation
specificity cross-talk
nucleotides
Online Access:http://www.mdpi.com/1424-8247/4/10/1328/

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http://www.mdpi.com/1424-8247/4/10/1328/

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