Antisecretory treatment: clear-cut benefit and potential risk

Proton pump inhibitors (PPI) remain a key element in the management of acid-dependent diseases. The antisecretory drug administration schedule should take into account the nature of the disease and the research data reflected in relevant international consensus. The patient’s adherence to the PPI in...

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Main Authors: S. I. Pimanov, E. V. Makarenko, E. A. Dikareva
Format: Article
Language:Russian
Published: Remedium Group LLC 2018-04-01
Series:Медицинский совет
Subjects:
Online Access:https://www.med-sovet.pro/jour/article/view/2450
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spelling doaj-cc94b49318e2483ab086745bc9b1afdb2021-07-28T13:29:35ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902018-04-0103263110.21518/2079-701X-2018-3-26-312424Antisecretory treatment: clear-cut benefit and potential riskS. I. Pimanov0E. V. Makarenko1E. A. Dikareva2Vitebsk State Medical UniversityVitebsk State Medical UniversityVitebsk State Medical UniversityProton pump inhibitors (PPI) remain a key element in the management of acid-dependent diseases. The antisecretory drug administration schedule should take into account the nature of the disease and the research data reflected in relevant international consensus. The patient’s adherence to the PPI intake has a significant impact on the results of management of acid-dependent diseases. The benefit of PPI intake significantly exceeds the potential harm that is low or very low. To date, there is no conclusive evidence of the adverse effects of the prolonged use of PPI, however, if there is no indication for the PPI intake, it is not recommended to use high doses of the drug. The pharmacodynamic effect of different PPIs doesn’t differ significantly, however, according to experts’ opinion based on meta-analysis, esomeprazole has some advantage over other drugs.https://www.med-sovet.pro/jour/article/view/2450proton pump inhibitorsside effectsgastric acid related diseasesgastroduodenal ulcergastroesophageal reflux diseasehelicobacter pyloriadherencenon-steroidal anti-inflammatory drugsclopidogrelesomeprazole
collection DOAJ
language Russian
format Article
sources DOAJ
author S. I. Pimanov
E. V. Makarenko
E. A. Dikareva
spellingShingle S. I. Pimanov
E. V. Makarenko
E. A. Dikareva
Antisecretory treatment: clear-cut benefit and potential risk
Медицинский совет
proton pump inhibitors
side effects
gastric acid related diseases
gastroduodenal ulcer
gastroesophageal reflux disease
helicobacter pylori
adherence
non-steroidal anti-inflammatory drugs
clopidogrel
esomeprazole
author_facet S. I. Pimanov
E. V. Makarenko
E. A. Dikareva
author_sort S. I. Pimanov
title Antisecretory treatment: clear-cut benefit and potential risk
title_short Antisecretory treatment: clear-cut benefit and potential risk
title_full Antisecretory treatment: clear-cut benefit and potential risk
title_fullStr Antisecretory treatment: clear-cut benefit and potential risk
title_full_unstemmed Antisecretory treatment: clear-cut benefit and potential risk
title_sort antisecretory treatment: clear-cut benefit and potential risk
publisher Remedium Group LLC
series Медицинский совет
issn 2079-701X
2658-5790
publishDate 2018-04-01
description Proton pump inhibitors (PPI) remain a key element in the management of acid-dependent diseases. The antisecretory drug administration schedule should take into account the nature of the disease and the research data reflected in relevant international consensus. The patient’s adherence to the PPI intake has a significant impact on the results of management of acid-dependent diseases. The benefit of PPI intake significantly exceeds the potential harm that is low or very low. To date, there is no conclusive evidence of the adverse effects of the prolonged use of PPI, however, if there is no indication for the PPI intake, it is not recommended to use high doses of the drug. The pharmacodynamic effect of different PPIs doesn’t differ significantly, however, according to experts’ opinion based on meta-analysis, esomeprazole has some advantage over other drugs.
topic proton pump inhibitors
side effects
gastric acid related diseases
gastroduodenal ulcer
gastroesophageal reflux disease
helicobacter pylori
adherence
non-steroidal anti-inflammatory drugs
clopidogrel
esomeprazole
url https://www.med-sovet.pro/jour/article/view/2450
work_keys_str_mv AT sipimanov antisecretorytreatmentclearcutbenefitandpotentialrisk
AT evmakarenko antisecretorytreatmentclearcutbenefitandpotentialrisk
AT eadikareva antisecretorytreatmentclearcutbenefitandpotentialrisk
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