Antisecretory treatment: clear-cut benefit and potential risk
Proton pump inhibitors (PPI) remain a key element in the management of acid-dependent diseases. The antisecretory drug administration schedule should take into account the nature of the disease and the research data reflected in relevant international consensus. The patient’s adherence to the PPI in...
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Remedium Group LLC
2018-04-01
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doaj-cc94b49318e2483ab086745bc9b1afdb2021-07-28T13:29:35ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902018-04-0103263110.21518/2079-701X-2018-3-26-312424Antisecretory treatment: clear-cut benefit and potential riskS. I. Pimanov0E. V. Makarenko1E. A. Dikareva2Vitebsk State Medical UniversityVitebsk State Medical UniversityVitebsk State Medical UniversityProton pump inhibitors (PPI) remain a key element in the management of acid-dependent diseases. The antisecretory drug administration schedule should take into account the nature of the disease and the research data reflected in relevant international consensus. The patient’s adherence to the PPI intake has a significant impact on the results of management of acid-dependent diseases. The benefit of PPI intake significantly exceeds the potential harm that is low or very low. To date, there is no conclusive evidence of the adverse effects of the prolonged use of PPI, however, if there is no indication for the PPI intake, it is not recommended to use high doses of the drug. The pharmacodynamic effect of different PPIs doesn’t differ significantly, however, according to experts’ opinion based on meta-analysis, esomeprazole has some advantage over other drugs.https://www.med-sovet.pro/jour/article/view/2450proton pump inhibitorsside effectsgastric acid related diseasesgastroduodenal ulcergastroesophageal reflux diseasehelicobacter pyloriadherencenon-steroidal anti-inflammatory drugsclopidogrelesomeprazole |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
S. I. Pimanov E. V. Makarenko E. A. Dikareva |
spellingShingle |
S. I. Pimanov E. V. Makarenko E. A. Dikareva Antisecretory treatment: clear-cut benefit and potential risk Медицинский совет proton pump inhibitors side effects gastric acid related diseases gastroduodenal ulcer gastroesophageal reflux disease helicobacter pylori adherence non-steroidal anti-inflammatory drugs clopidogrel esomeprazole |
author_facet |
S. I. Pimanov E. V. Makarenko E. A. Dikareva |
author_sort |
S. I. Pimanov |
title |
Antisecretory treatment: clear-cut benefit and potential risk |
title_short |
Antisecretory treatment: clear-cut benefit and potential risk |
title_full |
Antisecretory treatment: clear-cut benefit and potential risk |
title_fullStr |
Antisecretory treatment: clear-cut benefit and potential risk |
title_full_unstemmed |
Antisecretory treatment: clear-cut benefit and potential risk |
title_sort |
antisecretory treatment: clear-cut benefit and potential risk |
publisher |
Remedium Group LLC |
series |
Медицинский совет |
issn |
2079-701X 2658-5790 |
publishDate |
2018-04-01 |
description |
Proton pump inhibitors (PPI) remain a key element in the management of acid-dependent diseases. The antisecretory drug administration schedule should take into account the nature of the disease and the research data reflected in relevant international consensus. The patient’s adherence to the PPI intake has a significant impact on the results of management of acid-dependent diseases. The benefit of PPI intake significantly exceeds the potential harm that is low or very low. To date, there is no conclusive evidence of the adverse effects of the prolonged use of PPI, however, if there is no indication for the PPI intake, it is not recommended to use high doses of the drug. The pharmacodynamic effect of different PPIs doesn’t differ significantly, however, according to experts’ opinion based on meta-analysis, esomeprazole has some advantage over other drugs. |
topic |
proton pump inhibitors side effects gastric acid related diseases gastroduodenal ulcer gastroesophageal reflux disease helicobacter pylori adherence non-steroidal anti-inflammatory drugs clopidogrel esomeprazole |
url |
https://www.med-sovet.pro/jour/article/view/2450 |
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AT sipimanov antisecretorytreatmentclearcutbenefitandpotentialrisk AT evmakarenko antisecretorytreatmentclearcutbenefitandpotentialrisk AT eadikareva antisecretorytreatmentclearcutbenefitandpotentialrisk |
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