Renoprotective Effect of the Recombinant Anti-IL-6R Fusion Proteins by Inhibiting JAK2/STAT3 Signaling Pathway in Diabetic Nephropathy

Renoprotective Effect of the Recombinant Anti-IL-6R Fusion Proteins by Inhibiting JAK2/STAT3 Signaling Pathway in Diabetic Nephropathy

Diabetic nephropathy the main reason for end stage renal disease is a common microvascular complication in patients with type 1 and type 2 diabetes. The interleukin-6 (IL-6), acting as a pleiotropic cytokine, play key roles in main autoimmune disorders. The recombinant anti-IL-6R fusion proteins (VH...

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Bibliographic Details
Main Authors: Nanwen Zhang, Qingmei Zheng, Yaduan Wang, Juan Lin, He Wang, Rui Liu, Mengru Yan, Xiaofeng Chen, Juhua Yang, Xiaole Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
diabetic nephropathy
IL-6
GK rat
STZ
JAK2/STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.681424/full

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