A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT<sup>KO</sup> Pancreatic Ductal Adenocarcinoma Cells

A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT<sup>KO</sup> Pancreatic Ductal Adenocarcinoma Cells

In our previous study, we showed that a cystine transporter (xCT) plays a pivotal role in ferroptosis of pancreatic ductal adenocarcinoma (PDAC) cells in vitro. However, in vivo xCT<sup>KO</sup> cells grew normally indicating that a mechanism exists to drastically suppress the ferroptoti...

Full description

Bibliographic Details
Main Authors: Willian Meira, Boutaina Daher, Scott Kenneth Parks, Yann Cormerais, Jerome Durivault, Eric Tambutte, Jacques Pouyssegur, Milica Vučetić
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
cysteine-cystine shuttle
ferroptosis
resistance
tumor environment
cysteine transporters
Online Access:https://www.mdpi.com/2072-6694/13/6/1434

Internet

https://www.mdpi.com/2072-6694/13/6/1434

Similar Items