SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-B pathway

SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-B pathway

Chronic inflammation induced by amyloid-beta (Aβ) plays a key role in the development of age-related macular degeneration (AMD), and matrix metalloproteinase-9 (MMP-9), interleukin (IL)-6, and IL-8 may be associated with chronic inflammation in AMD. Sirtuin 1 (SIRT1) regulates inflammation via inhib...

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Bibliographic Details
Main Authors: L. Cao, C. Liu, F. Wang, H. Wang
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2013-08-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Amyloid-beta
SRT1720
Age-related macular degeneration
Barrier integrity
Tight junction
Matrix metalloproteinase-9
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800659&lng=en&tlng=en

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