Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ.

Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ.

Impairments in mitochondria and transcription are important factors in the pathogenesis of Huntington disease (HD), a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. This study investigated the effect of different metabolic states and peroxisome proliferator-...

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Bibliographic Details
Main Authors: Youngnam N Jin, Woong Y Hwang, Chulman Jo, Gail V W Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3262812?pdf=render

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http://europepmc.org/articles/PMC3262812?pdf=render

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