Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu

Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu

Aberrant inflammasome activation contributes to various chronic inflammatory diseases; however, pyroptosis of inflammasome-active cells promptly terminates local inflammasome response. Molecular mechanisms underlying prolonged inflammasome signaling thus require further elucidation. Here, we report...

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Bibliographic Details
Main Authors: Seunghwan Son, Sung-Hyun Yoon, Byeong Jun Chae, Inhwa Hwang, Do-Wan Shim, Young Ho Choe, Young-Min Hyun, Je-Wook Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
neutrophil
inflammasome
pyroptosis
DAMP
NLRP3 desensitization
SARM1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.746032/full

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