CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression
Dorsal root ganglion (DRG) neurons, which are sensitive to oxidative stress due to their anatomical and structural characteristics, play a complex role in the initiation and progression of diabetic bladder neuropathy. We investigated the hypothesis that the antioxidant and antiapoptotic effects of C...
Main Authors: | YaDong Liu, SiCong Zhang, Jun Xue, ZhongQing Wei, Ping Ao, BaiXin Shen, LiuCheng Ding |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2019-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2019/2053149 |
Similar Items
-
CGRP protects bladder smooth muscle cells stimulated by high glucose through inhibiting p38 MAPK pathway in vitro
by: Jun Xue, et al.
Published: (2021-04-01) -
Regulatory Mechanisms of Shear Stress on Transcription Factor Nrf2 and Heme Oxygenase-1 in Endothelial Cells─Role of PI3K and Akt
by: HSIAO, HUAI-YU, et al.
Published: (2003) -
Methamphetamine Induces Heme Oxygenase-1 Expression via Activation of PI3K/Akt pathway
by: Chin-Yu Lin, et al.
Published: (2007) -
Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling
by: Jong Ho Shin, et al.
Published: (2019-01-01) -
Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
by: Jose Angel Alonso-Piñeiro, et al.
Published: (2021-09-01)