The impact of a fine-scale population stratification on rare variant association test results.
Population stratification is a well-known confounding factor in both common and rare variant association analyses. Rare variants tend to be more geographically clustered than common variants, because of their more recent origin. However, it is not yet clear if population stratification at a very fin...
Main Authors: | Elodie Persyn, Richard Redon, Lise Bellanger, Christian Dina |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0207677 |
Similar Items
-
Fine-scale patterns of population stratification confound rare variant association tests.
by: Timothy D O'Connor, et al.
Published: (2013-01-01) -
DoEstRare: A statistical test to identify local enrichments in rare genomic variants associated with disease.
by: Elodie Persyn, et al.
Published: (2017-01-01) -
Analyse d’association de variants génétiques rares dans une population démographiquement stable
by: Persyn, Elodie
Published: (2017) -
On rare variants in principal component analysis of population stratification
by: Shengqing Ma, et al.
Published: (2020-03-01) -
Rare and low frequency variant stratification in the UK population: description and impact on association tests.
by: Marie-Claude Babron, et al.
Published: (2012-01-01)