Control of adaptive action selection by secondary motor cortex during flexible visual categorization

Control of adaptive action selection by secondary motor cortex during flexible visual categorization

Adaptive action selection during stimulus categorization is an important feature of flexible behavior. To examine neural mechanism underlying this process, we trained mice to categorize the spatial frequencies of visual stimuli according to a boundary that changed between blocks of trials in a sessi...

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Main Authors: Tian-Yi Wang, Jing Liu, Haishan Yao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
flexible behavior
computational model
chemogenetic manipulation
secondary motor cortex
in vivo recording
Online Access:https://elifesciences.org/articles/54474
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spelling doaj-cc602cd4abe24dd29d6045cbb898cbd12021-05-05T21:14:34ZengeLife Sciences Publications LtdeLife2050-084X2020-06-01910.7554/eLife.54474Control of adaptive action selection by secondary motor cortex during flexible visual categorizationTian-Yi Wang0https://orcid.org/0000-0001-6488-339XJing Liu1Haishan Yao2https://orcid.org/0000-0003-4974-9197Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Beijing, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Beijing, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, ChinaAdaptive action selection during stimulus categorization is an important feature of flexible behavior. To examine neural mechanism underlying this process, we trained mice to categorize the spatial frequencies of visual stimuli according to a boundary that changed between blocks of trials in a session. Using a model with a dynamic decision criterion, we found that sensory history was important for adaptive action selection after the switch of boundary. Bilateral inactivation of the secondary motor cortex (M2) impaired adaptive action selection by reducing the behavioral influence of sensory history. Electrophysiological recordings showed that M2 neurons carried more information about upcoming choice and previous sensory stimuli when sensorimotor association was being remapped than when it was stable. Thus, M2 causally contributes to flexible action selection during stimulus categorization, with the representations of upcoming choice and sensory history regulated by the demand to remap stimulus-action association.https://elifesciences.org/articles/54474flexible behaviorcomputational modelchemogenetic manipulationsecondary motor cortexin vivo recording
collection DOAJ
language English
format Article
sources DOAJ
author Tian-Yi Wang
Jing Liu
Haishan Yao
spellingShingle Tian-Yi Wang
Jing Liu
Haishan Yao
Control of adaptive action selection by secondary motor cortex during flexible visual categorization
eLife
flexible behavior
computational model
chemogenetic manipulation
secondary motor cortex
in vivo recording
author_facet Tian-Yi Wang
Jing Liu
Haishan Yao
author_sort Tian-Yi Wang
title Control of adaptive action selection by secondary motor cortex during flexible visual categorization
title_short Control of adaptive action selection by secondary motor cortex during flexible visual categorization
title_full Control of adaptive action selection by secondary motor cortex during flexible visual categorization
title_fullStr Control of adaptive action selection by secondary motor cortex during flexible visual categorization
title_full_unstemmed Control of adaptive action selection by secondary motor cortex during flexible visual categorization
title_sort control of adaptive action selection by secondary motor cortex during flexible visual categorization
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2020-06-01
description Adaptive action selection during stimulus categorization is an important feature of flexible behavior. To examine neural mechanism underlying this process, we trained mice to categorize the spatial frequencies of visual stimuli according to a boundary that changed between blocks of trials in a session. Using a model with a dynamic decision criterion, we found that sensory history was important for adaptive action selection after the switch of boundary. Bilateral inactivation of the secondary motor cortex (M2) impaired adaptive action selection by reducing the behavioral influence of sensory history. Electrophysiological recordings showed that M2 neurons carried more information about upcoming choice and previous sensory stimuli when sensorimotor association was being remapped than when it was stable. Thus, M2 causally contributes to flexible action selection during stimulus categorization, with the representations of upcoming choice and sensory history regulated by the demand to remap stimulus-action association.
topic flexible behavior
computational model
chemogenetic manipulation
secondary motor cortex
in vivo recording
url https://elifesciences.org/articles/54474
work_keys_str_mv AT tianyiwang controlofadaptiveactionselectionbysecondarymotorcortexduringflexiblevisualcategorization
AT jingliu controlofadaptiveactionselectionbysecondarymotorcortexduringflexiblevisualcategorization
AT haishanyao controlofadaptiveactionselectionbysecondarymotorcortexduringflexiblevisualcategorization
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