| Summary: | On our quest for new bioactive molecules from marine sources, two cyclic imines (<b>1</b>, <b>2</b>) were isolated from a dinoflagellate extract, inhibiting the growth of the respiratory syncytial virus (RSV). Compound <b>1</b> was identified as a known molecule portimine, while <b>2</b> was elucidated to be a new cyclic imine, named kabirimine. The absolute stereochemistry of <b>1</b> was determined by crystallographic work and chiral derivatization, whereas the structure of <b>2</b> was elucidated by means of spectroscopic analysis and computational study on all the possible isomers. Compound <b>1</b> showed potent cytotoxicity (CC<sub>50</sub> < 0.097 µM) against HEp2 cells, while <b>2</b> exhibited moderate antiviral activity against RSV with IC<sub>50</sub> = 4.20 µM (95% CI 3.31−5.33).
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