Comparative Hi-C Reveals that CTCF Underlies Evolution of Chromosomal Domain Architecture

Comparative Hi-C Reveals that CTCF Underlies Evolution of Chromosomal Domain Architecture

Topological domains are key architectural building blocks of chromosomes, but their functional importance and evolutionary dynamics are not well defined. We performed comparative high-throughput chromosome conformation capture (Hi-C) in four mammals and characterized the conservation and divergence...

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Bibliographic Details
Main Authors: Matteo Vietri Rudan, Christopher Barrington, Stephen Henderson, Christina Ernst, Duncan T. Odom, Amos Tanay, Suzana Hadjur
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715001126

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