Interfering with Tumor Hypoxia for Radiotherapy Optimization

Abstract Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical outcome. The significance of hypoxia in the development of resistance to radiotherapy has been recognized for decades and the search for hypoxia-targeting, radiosensitizing agents continues. This rev...

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Main Authors:	Irma Telarovic, Roland H. Wenger, Martin Pruschy
Format:	Article
Language:	English
Published:	BMC 2021-06-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	hypoxia radiotherapy SBRT radiosensitizers
Online Access:	https://doi.org/10.1186/s13046-021-02000-x

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spelling	doaj-cc4bc911314f4f43bb50c1a3e7cc36f62021-06-27T11:05:40ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662021-06-0140112610.1186/s13046-021-02000-xInterfering with Tumor Hypoxia for Radiotherapy OptimizationIrma Telarovic0Roland H. Wenger1Martin Pruschy2Laboratory for Applied Radiobiology, Department of Radiation Oncology, University Hospital Zurich, University of ZurichInstitute of Physiology, University of ZurichLaboratory for Applied Radiobiology, Department of Radiation Oncology, University Hospital Zurich, University of ZurichAbstract Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical outcome. The significance of hypoxia in the development of resistance to radiotherapy has been recognized for decades and the search for hypoxia-targeting, radiosensitizing agents continues. This review summarizes the main hypoxia-related processes relevant for radiotherapy on the subcellular, cellular and tissue level and discusses the significance of hypoxia in radiation oncology, especially with regard to the current shift towards hypofractionated treatment regimens. Furthermore, we discuss the strategies to interfere with hypoxia for radiotherapy optimization, and we highlight novel insights into the molecular pathways involved in hypoxia that might be utilized to increase the efficacy of radiotherapy.https://doi.org/10.1186/s13046-021-02000-xhypoxiaradiotherapySBRTradiosensitizers
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Irma Telarovic Roland H. Wenger Martin Pruschy
spellingShingle	Irma Telarovic Roland H. Wenger Martin Pruschy Interfering with Tumor Hypoxia for Radiotherapy Optimization Journal of Experimental & Clinical Cancer Research hypoxia radiotherapy SBRT radiosensitizers
author_facet	Irma Telarovic Roland H. Wenger Martin Pruschy
author_sort	Irma Telarovic
title	Interfering with Tumor Hypoxia for Radiotherapy Optimization
title_short	Interfering with Tumor Hypoxia for Radiotherapy Optimization
title_full	Interfering with Tumor Hypoxia for Radiotherapy Optimization
title_fullStr	Interfering with Tumor Hypoxia for Radiotherapy Optimization
title_full_unstemmed	Interfering with Tumor Hypoxia for Radiotherapy Optimization
title_sort	interfering with tumor hypoxia for radiotherapy optimization
publisher	BMC
series	Journal of Experimental & Clinical Cancer Research
issn	1756-9966
publishDate	2021-06-01
description	Abstract Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical outcome. The significance of hypoxia in the development of resistance to radiotherapy has been recognized for decades and the search for hypoxia-targeting, radiosensitizing agents continues. This review summarizes the main hypoxia-related processes relevant for radiotherapy on the subcellular, cellular and tissue level and discusses the significance of hypoxia in radiation oncology, especially with regard to the current shift towards hypofractionated treatment regimens. Furthermore, we discuss the strategies to interfere with hypoxia for radiotherapy optimization, and we highlight novel insights into the molecular pathways involved in hypoxia that might be utilized to increase the efficacy of radiotherapy.
topic	hypoxia radiotherapy SBRT radiosensitizers
url	https://doi.org/10.1186/s13046-021-02000-x
work_keys_str_mv	AT irmatelarovic interferingwithtumorhypoxiaforradiotherapyoptimization AT rolandhwenger interferingwithtumorhypoxiaforradiotherapyoptimization AT martinpruschy interferingwithtumorhypoxiaforradiotherapyoptimization
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Interfering with Tumor Hypoxia for Radiotherapy Optimization

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