Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review

Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review

Surface-Enhanced Raman Spectroscopy (SERS) is a label-free technique that enables quick monitoring of substances at low concentrations in biological matrices. These advantages make it an attractive tool for the development of point-of-care tests suitable for Therapeutic Drug Monitoring (TDM) of drug...

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Main Authors: Aleksandra Jaworska, Stefano Fornasaro, Valter Sergo, Alois Bonifacio
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Biosensors
Subjects:
SERS
TDM
drug monitoring
Individualized cancer chemotherapy
Online Access:http://www.mdpi.com/2079-6374/6/3/47
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spelling doaj-cc38d998d3e74cc08b8dcf9be6f12dab2020-11-25T01:07:20ZengMDPI AGBiosensors2079-63742016-09-01634710.3390/bios6030047bios6030047Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical ReviewAleksandra Jaworska0Stefano Fornasaro1Valter Sergo2Alois Bonifacio3Department of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, ItalyDepartment of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, ItalyDepartment of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, ItalyDepartment of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, ItalySurface-Enhanced Raman Spectroscopy (SERS) is a label-free technique that enables quick monitoring of substances at low concentrations in biological matrices. These advantages make it an attractive tool for the development of point-of-care tests suitable for Therapeutic Drug Monitoring (TDM) of drugs with a narrow therapeutic window, such as chemotherapeutic drugs, immunosuppressants, and various anticonvulsants. In this article, the current applications of SERS in the field of TDM for cancer therapy are discussed in detail and illustrated according to the different strategies and substrates. In particular, future perspectives are provided and special concerns regarding the standardization of self-assembly methods and nanofabrication procedures, quality assurance, and technology readiness are critically evaluated.http://www.mdpi.com/2079-6374/6/3/47SERSTDMdrug monitoringIndividualized cancer chemotherapy
collection DOAJ
language English
format Article
sources DOAJ
author Aleksandra Jaworska
Stefano Fornasaro
Valter Sergo
Alois Bonifacio
spellingShingle Aleksandra Jaworska
Stefano Fornasaro
Valter Sergo
Alois Bonifacio
Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review
Biosensors
SERS
TDM
drug monitoring
Individualized cancer chemotherapy
author_facet Aleksandra Jaworska
Stefano Fornasaro
Valter Sergo
Alois Bonifacio
author_sort Aleksandra Jaworska
title Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review
title_short Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review
title_full Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review
title_fullStr Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review
title_full_unstemmed Potential of Surface Enhanced Raman Spectroscopy (SERS) in Therapeutic Drug Monitoring (TDM). A Critical Review
title_sort potential of surface enhanced raman spectroscopy (sers) in therapeutic drug monitoring (tdm). a critical review
publisher MDPI AG
series Biosensors
issn 2079-6374
publishDate 2016-09-01
description Surface-Enhanced Raman Spectroscopy (SERS) is a label-free technique that enables quick monitoring of substances at low concentrations in biological matrices. These advantages make it an attractive tool for the development of point-of-care tests suitable for Therapeutic Drug Monitoring (TDM) of drugs with a narrow therapeutic window, such as chemotherapeutic drugs, immunosuppressants, and various anticonvulsants. In this article, the current applications of SERS in the field of TDM for cancer therapy are discussed in detail and illustrated according to the different strategies and substrates. In particular, future perspectives are provided and special concerns regarding the standardization of self-assembly methods and nanofabrication procedures, quality assurance, and technology readiness are critically evaluated.
topic SERS
TDM
drug monitoring
Individualized cancer chemotherapy
url http://www.mdpi.com/2079-6374/6/3/47
work_keys_str_mv AT aleksandrajaworska potentialofsurfaceenhancedramanspectroscopysersintherapeuticdrugmonitoringtdmacriticalreview
AT stefanofornasaro potentialofsurfaceenhancedramanspectroscopysersintherapeuticdrugmonitoringtdmacriticalreview
AT valtersergo potentialofsurfaceenhancedramanspectroscopysersintherapeuticdrugmonitoringtdmacriticalreview
AT aloisbonifacio potentialofsurfaceenhancedramanspectroscopysersintherapeuticdrugmonitoringtdmacriticalreview
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