Insulin receptor sensitization restores neocortical excitation/inhibition balance in a mouse model of autism

Insulin receptor sensitization restores neocortical excitation/inhibition balance in a mouse model of autism

Abstract Background Met receptor tyrosine kinase regulates neurogenesis, differentiation, migration, connectivity, and synaptic plasticity. The human Met gene has been identified as a prominent risk factor for autism spectrum disorder (ASD). Met gene-altered mice serve as useful models for mechanist...

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Bibliographic Details
Main Authors: Fu-Sun Lo, Reha S. Erzurumlu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Autism
Subjects:
Met receptor tyrosine kinase
Barrel cortex
Homeostatic plasticity
GABAA receptors
Pioglitazone
Thalamocortical circuitry
Online Access:http://link.springer.com/article/10.1186/s13229-018-0196-6

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http://link.springer.com/article/10.1186/s13229-018-0196-6

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