Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain

Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain

Changes in sphingolipid metabolism have been suggested to contribute to the pathophysiology of major depression. In this study, we investigated the activity of acid and neutral sphingomyelinases (ASM, NSM) and ceramidases (AC, NC), respectively, in twelve brain regions of female rats selectively bre...

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Bibliographic Details
Main Authors: Iulia Zoicas, Christiane Mühle, Anna K. Schmidtner, Erich Gulbins, Inga D. Neumann, Johannes Kornhuber
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
anxiety
depression
sphingolipids
sphingomyelinase
ceramidase
Online Access:https://www.mdpi.com/2073-4409/9/5/1239

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