Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders

Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders

Many adult stem cell communities are maintained by population asymmetry, where stochastic behaviors of multiple individual cells collectively result in a balance between stem cell division and differentiation. We investigated how this is achieved for Drosophila Follicle Stem Cells (FSCs) by spatiall...

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Bibliographic Details
Main Authors: David Melamed, Daniel Kalderon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
Follicle Stem Cells
Stem Cells
JAK-STAT
Wnt
signaling
niche
Online Access:https://elifesciences.org/articles/61204

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