Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis
Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00551-2 |
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doaj-cc1ca07b42ef444d8f0ceca3934d4c402021-05-11T07:05:38ZengNature Publishing GroupNature Communications2041-17232017-09-018111810.1038/s41467-017-00551-2Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesisZhiping Liu0Siyuan Yan1Jiaojiao Wang2Yiming Xu3Yong Wang4Shuya Zhang5Xizhen Xu6Qiuhua Yang7Xianqiu Zeng8Yaqi Zhou9Xuejiao Gu10Sarah Lu11Zhongjie Fu12David J. Fulton13Neal L. Weintraub14Ruth B. Caldwell15Wenbo Zhang16Chaodong Wu17Xiao-Ling Liu18Jiang-Fan Chen19Aftab Ahmad20Ismail Kaddour-Djebbar21Mohamed Al-Shabrawey22Qinkai Li23Xuejun Jiang24Ye Sun25Akrit Sodhi26Lois Smith27Mei Hong28Yuqing Huo29Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate SchoolVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityDrug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate SchoolVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical UniversityVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityDrug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate SchoolDrug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate SchoolDrug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate SchoolMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical UniversityVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityDepartment of Ophthalmology, Boston Children’s Hospital, Harvard Medical SchoolVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityDepartment of Ophthalmology & Visual Sciences, University of Texas Medical Branch (UTMB)Department of Nutrition and Food Science, Texas A&M UniversityMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical UniversityMolecular Neuropharmacology Laboratory, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical UniversityDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at BirminghamDepartment of Physiology, Medical College of Georgia, Augusta UniversityJames and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta UniversityDrug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate SchoolState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of ScienceDepartment of Ophthalmology, Boston Children’s Hospital, Harvard Medical SchoolWilmer Eye Institute, Johns Hopkins School of MedicineDepartment of Ophthalmology, Boston Children’s Hospital, Harvard Medical SchoolDrug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate SchoolVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta UniversityPathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new therapeutic targets for disease treatment.https://doi.org/10.1038/s41467-017-00551-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zhiping Liu Siyuan Yan Jiaojiao Wang Yiming Xu Yong Wang Shuya Zhang Xizhen Xu Qiuhua Yang Xianqiu Zeng Yaqi Zhou Xuejiao Gu Sarah Lu Zhongjie Fu David J. Fulton Neal L. Weintraub Ruth B. Caldwell Wenbo Zhang Chaodong Wu Xiao-Ling Liu Jiang-Fan Chen Aftab Ahmad Ismail Kaddour-Djebbar Mohamed Al-Shabrawey Qinkai Li Xuejun Jiang Ye Sun Akrit Sodhi Lois Smith Mei Hong Yuqing Huo |
| spellingShingle |
Zhiping Liu Siyuan Yan Jiaojiao Wang Yiming Xu Yong Wang Shuya Zhang Xizhen Xu Qiuhua Yang Xianqiu Zeng Yaqi Zhou Xuejiao Gu Sarah Lu Zhongjie Fu David J. Fulton Neal L. Weintraub Ruth B. Caldwell Wenbo Zhang Chaodong Wu Xiao-Ling Liu Jiang-Fan Chen Aftab Ahmad Ismail Kaddour-Djebbar Mohamed Al-Shabrawey Qinkai Li Xuejun Jiang Ye Sun Akrit Sodhi Lois Smith Mei Hong Yuqing Huo Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis Nature Communications |
| author_facet |
Zhiping Liu Siyuan Yan Jiaojiao Wang Yiming Xu Yong Wang Shuya Zhang Xizhen Xu Qiuhua Yang Xianqiu Zeng Yaqi Zhou Xuejiao Gu Sarah Lu Zhongjie Fu David J. Fulton Neal L. Weintraub Ruth B. Caldwell Wenbo Zhang Chaodong Wu Xiao-Ling Liu Jiang-Fan Chen Aftab Ahmad Ismail Kaddour-Djebbar Mohamed Al-Shabrawey Qinkai Li Xuejun Jiang Ye Sun Akrit Sodhi Lois Smith Mei Hong Yuqing Huo |
| author_sort |
Zhiping Liu |
| title |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_short |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_full |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_fullStr |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_full_unstemmed |
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| title_sort |
endothelial adenosine a2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-09-01 |
| description |
Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new therapeutic targets for disease treatment. |
| url |
https://doi.org/10.1038/s41467-017-00551-2 |
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