Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis
Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new...
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Bibliographic Details
| Main Authors: |
Zhiping Liu,
Siyuan Yan,
Jiaojiao Wang,
Yiming Xu,
Yong Wang,
Shuya Zhang,
Xizhen Xu,
Qiuhua Yang,
Xianqiu Zeng,
Yaqi Zhou,
Xuejiao Gu,
Sarah Lu,
Zhongjie Fu,
David J. Fulton,
Neal L. Weintraub,
Ruth B. Caldwell,
Wenbo Zhang,
Chaodong Wu,
Xiao-Ling Liu,
Jiang-Fan Chen,
Aftab Ahmad,
Ismail Kaddour-Djebbar,
Mohamed Al-Shabrawey,
Qinkai Li,
Xuejun Jiang,
Ye Sun,
Akrit Sodhi,
Lois Smith,
Mei Hong,
Yuqing Huo |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-00551-2
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