Kinetic modeling of 68Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients

Kinetic modeling of 68Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients

Abstract Background The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeli...

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Bibliographic Details
Main Authors: Anna Ringheim, Guilherme de Carvalho Campos Neto, Udunna Anazodo, Lumeng Cui, Marcelo Livorsi da Cunha, Taise Vitor, Karine Minaif Martins, Ana Cláudia Camargo Miranda, Marycel Figols de Barboza, Leonardo Lima Fuscaldi, Gustavo Caserta Lemos, José Roberto Colombo Junior, Ronaldo Hueb Baroni
Format: Article
Language:English
Published: SpringerOpen 2020-02-01
Series:EJNMMI Research
Subjects:
Prostate cancer
PSMA
PET/MR
Kinetic modeling
Arterial blood sampling
Image-derived input function
Online Access:http://link.springer.com/article/10.1186/s13550-020-0594-6

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http://link.springer.com/article/10.1186/s13550-020-0594-6

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