Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9

Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motoneurons in the primary motor cortex (pMO) and in spinal cord. However, the pathogenic process involves multiple subnetworks in the brain and functional MRI studies demonstrate an increase in functional connec...

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Bibliographic Details
Main Authors: Barbara Commisso, Lingjun Ding, Karl Varadi, Martin Gorges, David Bayer, Tobias M Boeckers, Albert C Ludolph, Jan Kassubek, Oliver J Müller, Francesco Roselli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
amyotrophic lateral sclerosis
primary motor cortex
AAV9
retrograde tracing
Online Access:https://elifesciences.org/articles/36892

Internet

https://elifesciences.org/articles/36892

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