Pathogenetic features of endothelial dysfunction at respiratory-cardiac comorbidity

• Main Authors: A. Kh. Akhmineeva, O. S. Polunina, I. V. Sevostyanova, L. P. Voronina
• Format: Article
• Language: Russian
• Published: Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” 2014-08-01
• Series: Кубанский научный медицинский вестник
• Subjects: хроническая обструктивная болезнь легких; бронхиальная астма; ишемическая болезнь сердца; артериальная гипертензия; эндотелиальная дисфункция; системное воспаление; chronic obstructive pulmonary disease; bronchial asthma; coronary heart disease; arterial hypertension; endothelial dysfunction; systemic inflammation
• Online Access: https://ksma.elpub.ru/jour/article/view/168

A correlation analysis to identify the relationship between markers of endothelial dysfunction (coefficient of endothelial function - EFC, type C natriuretic peptide, endothelin-1) and indicators reflecting the activity of inflammation (C - reactive protein, fractalkine) in patients with chronic obstructive pulmonary disease (COPD), bronchial asthma (BA), coronary heart disease (CHD), arterial hypertension (AH) and in patients with comorbidity (COPD+CHD, COPD+AH, BA+ CHD, BA+AH). It was revealed that at comorbid combinations COPD+AG, BA+AG basic mechanism of development of endothelial dysfunction is the activation of chemotactic inflammatory cascade with hyperproduction of fractalkine. C-reactive protein, fractalkine are diagnostic and prognostic markers defeat of endothelium in patients with combinations of COPD+ CHD, BA+CHD.