Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s Disease

Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s Disease

Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during tr...

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Main Authors: L. Schelosky, Th. Benke, W. Poewe
Format: Article
Language:English
Published: Hindawi Limited 1991-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.3233/BEN-1991-4206
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spelling doaj-cc0a75783d9f43fca089b9e251f309aa2021-07-02T04:51:24ZengHindawi LimitedBehavioural Neurology0953-41801875-85841991-01-014210311110.3233/BEN-1991-4206Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s DiseaseL. Schelosky0Th. Benke1W. Poewe2Department of Neurology, UKRV, Spandauer Damm 130, Berlin 19, GermanyUniversity Hospital for Neurology, 6020 Innsbruck, Anichstr. 35, AustriaDepartment of Neurology, UKRV, Spandauer Damm 130, Berlin 19, GermanyThirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphenidyl. Retesting after anticholinergic exposure (mean of 2 weeks for patients and 1 week for controls) revealed in young healthy controls the same pattern and magnitude of decline in memory function as in Parkinson patients. Non-demented subjects with Parkinson's disease of recent onset thus do riot seem to be selectively vulnerable to cognitive side-effects of anticholinergic treatment.http://dx.doi.org/10.3233/BEN-1991-4206
collection DOAJ
language English
format Article
sources DOAJ
author L. Schelosky
Th. Benke
W. Poewe
spellingShingle L. Schelosky
Th. Benke
W. Poewe
Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s Disease
Behavioural Neurology
author_facet L. Schelosky
Th. Benke
W. Poewe
author_sort L. Schelosky
title Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s Disease
title_short Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s Disease
title_full Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s Disease
title_fullStr Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s Disease
title_full_unstemmed Lack of Selective Vulnerability to Anticholinergic Induced Cognitive Impairment in Early Parkinson’s Disease
title_sort lack of selective vulnerability to anticholinergic induced cognitive impairment in early parkinson’s disease
publisher Hindawi Limited
series Behavioural Neurology
issn 0953-4180
1875-8584
publishDate 1991-01-01
description Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphenidyl. Retesting after anticholinergic exposure (mean of 2 weeks for patients and 1 week for controls) revealed in young healthy controls the same pattern and magnitude of decline in memory function as in Parkinson patients. Non-demented subjects with Parkinson's disease of recent onset thus do riot seem to be selectively vulnerable to cognitive side-effects of anticholinergic treatment.
url http://dx.doi.org/10.3233/BEN-1991-4206
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AT thbenke lackofselectivevulnerabilitytoanticholinergicinducedcognitiveimpairmentinearlyparkinsonsdisease
AT wpoewe lackofselectivevulnerabilitytoanticholinergicinducedcognitiveimpairmentinearlyparkinsonsdisease
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