EXPERIMENTAL MODEL OF THE PRIMARY MALE HYPOGONADISM

• Main Authors: P. A. Kulikova, Yu. N. Filyushkin, D. A. Kulikov, A. V. Fedulov, A. E. Mashkov, A. V. Kulikov
• Format: Article
• Language: Russian
• Published: MONIKI 2016-02-01
• Series: Alʹmanah Kliničeskoj Mediciny
• Subjects: hypogonadism; experimental model; testicles; testosterone; ischemia; infertility
• Online Access: https://www.almclinmed.ru/jour/article/view/53

Background: Development of the new methods of treatment of primary male hypogonadism is an urgent medical problem. Its solution requires a suitable experimental model of the disease. Aim: The creation of new experimental model of primary male hypogonadism. Materials and methods: The study was conducted on the male Wistar rats, hypogonadism was modeled by temporary ligation of the distal part of the spermatic cord. Results: It was shown that three-day ligation of the spermatic cord led to persistent disturbance of the testosterone-producing and reproductive functions. These manifestations were reversible at shorter duration of the exposure. Conclusion: The created model of primary male hypogonadism is characterized by the persistent testosterone-producing and reproductive functions disturbance, technical availability, non-toxicity to the other organs and systems. Availability of the model provides new opportunities for the development of approaches to treating diseases of the reproductive organs in men.