ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells

ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells

Abstract Genes encoding replication-dependent histones lack introns, and the mRNAs produced are a unique class of RNA polymerase II transcripts in eukaryotic cells that do not end in a polyadenylated tail. Mature mRNAs are thus formed by a single endonucleolytic cleavage that releases the pre-mRNA f...

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Bibliographic Details
Main Authors: Ankur Gadgil, Agnieszka Walczak, Agata Stępień, Jonas Mechtersheimer, Agnes Lumi Nishimura, Christopher E. Shaw, Marc-David Ruepp, Katarzyna Dorota Raczyńska
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91453-3

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