Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives

Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives

Aminothiazole derivatives of 4-hydroxy-2H-chromen-2-one were prepared by the Hantzsch reaction1 using 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one and thiourea derivatives. Starting compound for this synthesis 3-(2-bromoacetyl)-4-hydroxy- 2H-chromen-2-one (1) was prepared previously.2 Also, for this...

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Main Authors: Sukdolak S., Vuković N., Solujić S., Milošev M., Manojlović N., Krstić Lj.
Format: Article
Language:English
Published: Serbian Chemical Society 2006-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
hantzsch reaction
3-(2-aminothiazol-4-yl)-4-hydroxy-2h-chromen-2-onederivatives
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390606581S.pdf
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spelling doaj-cbff64da4b2a49a394ad7fd9a0e1ba4d2020-12-24T14:30:36ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51391820-74212006-01-0171658158510.2298/JSC0606581S0352-51390606581SSynthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivativesSukdolak S.0Vuković N.1Solujić S.2Milošev M.3Manojlović N.4Krstić Lj.5Prirodno-matematički fakultet, Institut za hemiju, KragujevacPrirodno-matematički fakultet, Institut za hemiju, KragujevacPrirodno-matematički fakultet, Institut za hemiju, KragujevacPrirodno-matematički fakultet, Institut za hemiju, KragujevacPrirodno-matematički fakultet, Institut za hemiju, KragujevacIHTM, Centar za hemiju, BeogradAminothiazole derivatives of 4-hydroxy-2H-chromen-2-one were prepared by the Hantzsch reaction1 using 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one and thiourea derivatives. Starting compound for this synthesis 3-(2-bromoacetyl)-4-hydroxy- 2H-chromen-2-one (1) was prepared previously.2 Also, for this synthesis we used thiourea derivatives (2a-j) as compounds which possess groups with biological activity. Reactions are carried out in refluxing ethanol for a period of 30 - 45 min. Final products (3a-j) are obtained in a high yield. Chemical structure of the obtained compounds was confirmed by elemental and structural analysis (IR and 1H NMR spectroscopy).http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390606581S.pdfhantzsch reaction3-(2-aminothiazol-4-yl)-4-hydroxy-2h-chromen-2-onederivatives
collection DOAJ
language English
format Article
sources DOAJ
author Sukdolak S.
Vuković N.
Solujić S.
Milošev M.
Manojlović N.
Krstić Lj.
spellingShingle Sukdolak S.
Vuković N.
Solujić S.
Milošev M.
Manojlović N.
Krstić Lj.
Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
Journal of the Serbian Chemical Society
hantzsch reaction
3-(2-aminothiazol-4-yl)-4-hydroxy-2h-chromen-2-onederivatives
author_facet Sukdolak S.
Vuković N.
Solujić S.
Milošev M.
Manojlović N.
Krstić Lj.
author_sort Sukdolak S.
title Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
title_short Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
title_full Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
title_fullStr Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
title_full_unstemmed Synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one derivatives
title_sort synthesis of new 3-(2-aminothiazol-4-yl)-4-hydroxy-2h-chromen-2-one derivatives
publisher Serbian Chemical Society
series Journal of the Serbian Chemical Society
issn 0352-5139
1820-7421
publishDate 2006-01-01
description Aminothiazole derivatives of 4-hydroxy-2H-chromen-2-one were prepared by the Hantzsch reaction1 using 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one and thiourea derivatives. Starting compound for this synthesis 3-(2-bromoacetyl)-4-hydroxy- 2H-chromen-2-one (1) was prepared previously.2 Also, for this synthesis we used thiourea derivatives (2a-j) as compounds which possess groups with biological activity. Reactions are carried out in refluxing ethanol for a period of 30 - 45 min. Final products (3a-j) are obtained in a high yield. Chemical structure of the obtained compounds was confirmed by elemental and structural analysis (IR and 1H NMR spectroscopy).
topic hantzsch reaction
3-(2-aminothiazol-4-yl)-4-hydroxy-2h-chromen-2-onederivatives
url http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390606581S.pdf
work_keys_str_mv AT sukdolaks synthesisofnew32aminothiazol4yl4hydroxy2hchromen2onederivatives
AT vukovicn synthesisofnew32aminothiazol4yl4hydroxy2hchromen2onederivatives
AT solujics synthesisofnew32aminothiazol4yl4hydroxy2hchromen2onederivatives
AT milosevm synthesisofnew32aminothiazol4yl4hydroxy2hchromen2onederivatives
AT manojlovicn synthesisofnew32aminothiazol4yl4hydroxy2hchromen2onederivatives
AT krsticlj synthesisofnew32aminothiazol4yl4hydroxy2hchromen2onederivatives
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