Temporal Airy pulses control cell poration

Temporal Airy pulses control cell poration

We show that spectral phase shaping of fs-laser pulses can be used to optimize laser-cell membrane interactions in water environment. The energy and peak intensity thresholds required for cell poration with single pulse in the nJ range can be significantly reduced (25% reduction in energy and 88% re...

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Main Authors: S. Courvoisier, N. Götte, B. Zielinski, T. Winkler, C. Sarpe, A. Senftleben, L. Bonacina, J. P. Wolf, T. Baumert
Format: Article
Language:English
Published: AIP Publishing LLC 2016-07-01
Series:APL Photonics
Online Access:http://dx.doi.org/10.1063/1.4948367
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spelling doaj-cbf3036ed12f406ea76f1021528433dc2020-11-24T20:42:57ZengAIP Publishing LLCAPL Photonics2378-09672016-07-0114046102046102-710.1063/1.4948367001602APPTemporal Airy pulses control cell porationS. Courvoisier0N. Götte1B. Zielinski2T. Winkler3C. Sarpe4A. Senftleben5L. Bonacina6J. P. Wolf7T. Baumert8GAP-Biophotonics, University of Geneva, ch. de Pinchat 22, 1211 Geneva 4, SwitzerlandExperimentalphysik, Universitaet Kassel, Heinr.-Plett-Straße 40, 34132 Kassel, GermanyExperimentalphysik, Universitaet Kassel, Heinr.-Plett-Straße 40, 34132 Kassel, GermanyExperimentalphysik, Universitaet Kassel, Heinr.-Plett-Straße 40, 34132 Kassel, GermanyExperimentalphysik, Universitaet Kassel, Heinr.-Plett-Straße 40, 34132 Kassel, GermanyExperimentalphysik, Universitaet Kassel, Heinr.-Plett-Straße 40, 34132 Kassel, GermanyGAP-Biophotonics, University of Geneva, ch. de Pinchat 22, 1211 Geneva 4, SwitzerlandGAP-Biophotonics, University of Geneva, ch. de Pinchat 22, 1211 Geneva 4, SwitzerlandExperimentalphysik, Universitaet Kassel, Heinr.-Plett-Straße 40, 34132 Kassel, GermanyWe show that spectral phase shaping of fs-laser pulses can be used to optimize laser-cell membrane interactions in water environment. The energy and peak intensity thresholds required for cell poration with single pulse in the nJ range can be significantly reduced (25% reduction in energy and 88% reduction in peak intensity) by using temporal Airy pulses, controlled by positive third order dispersion, as compared to bandwidth limited pulses. Temporal Airy pulses are also effective to control the morphology of the induced pores, with prospective applications from cellular to tissue opto-surgery and transfection.http://dx.doi.org/10.1063/1.4948367
collection DOAJ
language English
format Article
sources DOAJ
author S. Courvoisier
N. Götte
B. Zielinski
T. Winkler
C. Sarpe
A. Senftleben
L. Bonacina
J. P. Wolf
T. Baumert
spellingShingle S. Courvoisier
N. Götte
B. Zielinski
T. Winkler
C. Sarpe
A. Senftleben
L. Bonacina
J. P. Wolf
T. Baumert
Temporal Airy pulses control cell poration
APL Photonics
author_facet S. Courvoisier
N. Götte
B. Zielinski
T. Winkler
C. Sarpe
A. Senftleben
L. Bonacina
J. P. Wolf
T. Baumert
author_sort S. Courvoisier
title Temporal Airy pulses control cell poration
title_short Temporal Airy pulses control cell poration
title_full Temporal Airy pulses control cell poration
title_fullStr Temporal Airy pulses control cell poration
title_full_unstemmed Temporal Airy pulses control cell poration
title_sort temporal airy pulses control cell poration
publisher AIP Publishing LLC
series APL Photonics
issn 2378-0967
publishDate 2016-07-01
description We show that spectral phase shaping of fs-laser pulses can be used to optimize laser-cell membrane interactions in water environment. The energy and peak intensity thresholds required for cell poration with single pulse in the nJ range can be significantly reduced (25% reduction in energy and 88% reduction in peak intensity) by using temporal Airy pulses, controlled by positive third order dispersion, as compared to bandwidth limited pulses. Temporal Airy pulses are also effective to control the morphology of the induced pores, with prospective applications from cellular to tissue opto-surgery and transfection.
url http://dx.doi.org/10.1063/1.4948367
work_keys_str_mv AT scourvoisier temporalairypulsescontrolcellporation
AT ngotte temporalairypulsescontrolcellporation
AT bzielinski temporalairypulsescontrolcellporation
AT twinkler temporalairypulsescontrolcellporation
AT csarpe temporalairypulsescontrolcellporation
AT asenftleben temporalairypulsescontrolcellporation
AT lbonacina temporalairypulsescontrolcellporation
AT jpwolf temporalairypulsescontrolcellporation
AT tbaumert temporalairypulsescontrolcellporation
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