A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.

A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.

Gauging the systemic effects of non-synonymous single nucleotide polymorphisms (nsSNPs) is an important topic in the pursuit of personalized medicine. However, it is a non-trivial task to understand how a change at the protein structure level eventually affects a cell's behavior. This is becaus...

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Bibliographic Details
Main Authors:	Tammy M K Cheng, Lucas Goehring, Linda Jeffery, Yu-En Lu, Jacqueline Hayles, Béla Novák, Paul A Bates
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS Computational Biology
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23093928/pdf/?tool=EBI

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