The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.

Accurate genome duplication underlies genetic homeostasis. Metazoan Mdm2 binding protein (MTBP) forms a main regulatory platform for origin firing together with Treslin/TICRR and TopBP1 (Topoisomerase II binding protein 1 (TopBP1)-interacting replication stimulating protein/TopBP1-interacting checkp...

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Bibliographic Details
Main Authors: Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P Ponting, Ambrosius P Snijders, Regina Feederle, Aloys Schepers, Dominik Boos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2006767

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