A Transcriptomic and Epigenomic Comparison of Fetal and Adult Human Cardiac Fibroblasts Reveals Novel Key Transcription Factors in Adult Cardiac Fibroblasts

A Transcriptomic and Epigenomic Comparison of Fetal and Adult Human Cardiac Fibroblasts Reveals Novel Key Transcription Factors in Adult Cardiac Fibroblasts

Cardiovascular disease remains the number one global cause of death and presents as multiple phenotypes in which the interplay between cardiomyocytes and cardiac fibroblasts (CFs) has become increasingly highlighted. Fetal and adult CFs influence neighboring cardiomyocytes in different ways. Thus fa...

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Bibliographic Details
Main Authors: Malin K.B. Jonsson, PhD, Robin J.G. Hartman, MSc, Matthew Ackers-Johnson, PhD, Wilson L.W. Tan, BSc, Bing Lim, MD, PhD, Toon A.B. van Veen, PhD, Roger S. Foo, MD
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:JACC: Basic to Translational Science
Subjects:
cardiac fibroblasts
collagen
histone methylation
transcriptome
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16301140
Description
Summary:Cardiovascular disease remains the number one global cause of death and presents as multiple phenotypes in which the interplay between cardiomyocytes and cardiac fibroblasts (CFs) has become increasingly highlighted. Fetal and adult CFs influence neighboring cardiomyocytes in different ways. Thus far, a detailed comparison between the two is lacking. Using a genome-wide approach, we identified and validated 2 crucial players for maintaining the adult primary human CF phenotype. Knockdown of these factors induced significant phenotypical changes, including senescence and reduced collagen gene expression. These may now represent novel therapeutic targets against deleterious functions of CFs in adult cardiovascular disease.
ISSN:2452-302X

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