Prediction of Positions of Active Compounds Makes It Possible To Increase Activity in Fragment-Based Drug Development

We have developed a computational method that predicts the positions of active compounds, making it possible to increase activity as a fragment evolution strategy. We refer to the positions of these compounds as the active position. When an active fragment compound is found, the following lead gener...

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Bibliographic Details
Main Author: Yoshifumi Fukunishi
Format: Article
Language:English
Published: MDPI AG 2011-05-01
Series:Pharmaceuticals
Subjects:
Online Access:http://www.mdpi.com/1424-8247/4/5/758/

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